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  Williams Syndrome 
  
Reviewed  07-01-2001  

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Table of Contents (click to jump to sections)

What is Williams Syndrome?
Is there any treatment?
What is the prognosis?
What research is being done?

Organizations

What is Williams Syndrome?
Williams syndrome is a rare, congenital (present at birth) disorder characterized by physical and developmental problems including an impulsive and outgoing (excessively social) personality, limited spatial skills and motor control, and intellectual disability (i.e., developmental delay, learning disabilities, mental retardation, or attention deficit disorder). Other features include characteristic "elfin-like" facial features, heart and blood vessel problems, hypercalcemia (elevated blood calcium levels), low birth weight, slow weight gain, feeding problems, irritability during infancy, dental and kidney abnormalities, hyperacusis (sensitive hearing), and musculoskeletal problems. Symptoms vary among patients. Although individuals with Williams syndrome may show competence in areas such as language, music, and interpersonal relations, their IQs are usually below average, and they are considered moderately to mildly retarded. Scientists have learned that most individuals with Williams syndrome have a deletion of genetic material on chromosome 7. This probably causes the physical and developmental problems experienced by patients.

Is there any treatment?
There is neither a cure for Williams syndrome nor a standard course of treatment. Treatment is symptomatic and supportive. Individuals with Williams syndrome need regular monitoring for potential medical problems by a physician familiar with the disorder, as well as specialized services to maximize their potential.

What is the prognosis?
The prognosis for individuals with Williams syndrome varies. Some may be able to master self-help skills, complete academic or vocational school, and live in supervised homes or on their own, while others may not progress to this level.

What research is being done?
The NINDS supports research on the neurological, behavioral, and genetic components of Williams syndrome.

Select this link to view a list of studies currently seeking patients.

 Organizations

National Organization for Rare Disorders (NORD)
P.O. Box 1968
(55 Kenosia Avenue)
Danbury, CT 06813-1968
orphan@rarediseases.org
http://www.rarediseases.org
Tel: 203-744-0100 Voice Mail 800-999-NORD (6673)
Fax: 203-798-2291

National Heart, Lung, and Blood Institute (NHBLI)
National Institutes of Health
Bldg. 31, Rm. 4A21
Bethesda, MD 20892
http://www.nhlbi.nih.gov
Tel: 301-592-8573 800-575-WELL (-9355)

National Institute of Child Health and Human Development (NICHD)
National Institutes of Health
Bldg. 31, Rm. 2A32
Bethesda, MD 20892-2425
NICHDClearinghouse@mail.nih.gov
http://www.nichd.nih.gov
Tel: 301-496-5133 800-370-2943

Williams Syndrome Association
P.O. Box 297
Clawson, MI 48017-0297
Tmonkaba@aol.com
http://www.williams-syndrome.org
Tel: 248-244-2229
Fax: 248-244-2230


NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history.

All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.


Provided by:
The National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892




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