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  Striatonigral Degeneration 
  
Reviewed  11-6-2002  

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What is Striatonigral Degeneration?
Is there any treatment?
What is the prognosis?
What research is being done?

Organizations

What is Striatonigral Degeneration?
Striatonigral degeneration is a neurological disorder caused by a disruption in the connection between two areas of the brain-the striatum and the substantia nigra. These two areas work together to enable balance and movement. Striatonigral degeneration is a type of multiple system atrophy (MSA). Symptoms of the disorder resemble some of those seen in Parkinson's disease, including rigidity, instability, impaired speech, and slow movements.

Is there any treatment?
There is no cure for striatonigral degeneration, and treatments for the disorder have variable success. Treatments used for Parkinson's disease are recommended. However, unlike Parkinson's disease, striatonigral degeneration is not responsive to levodopa. Dopamine and anticholinergics provide some benefit. Generally, treatment is reevaluated as the disorder progresses.

What is the prognosis?
Striatonigral degeneration progresses slowly. Some patients have normal life expectancy.

What research is being done?
The NINDS supports and conducts research on disorders of the brain and nervous system such as striatonigral degeneration. This research focuses on finding ways to prevent and treat these disorders.

Select this link to view a list of studies currently seeking patients.

 Organizations

Worldwide Education & Awareness for Movement Disorders (WE MOVE)
204 West 84th Street
New York, NY 10024
wemove@wemove.org
http://www.wemove.org
Tel: 800-437-MOV2 (6682) 212-875-8312
Fax: 212-875-8389

National Organization for Rare Disorders (NORD)
P.O. Box 1968
(55 Kenosia Avenue)
Danbury, CT 06813-1968
orphan@rarediseases.org
http://www.rarediseases.org
Tel: 203-744-0100 Voice Mail 800-999-NORD (6673)
Fax: 203-798-2291

American Parkinson Disease Association
1250 Hylan Blvd.
Suite 4B
Staten Island, NY 10305-1946
apda@apdaparkinson.org
http://www.apdaparkinson.org
Tel: 718-981-8001 800-223-2732 Calif: 800-908-2732
Fax: 718-981-4399

National Parkinson Foundation
1501 N.W. 9th Avenue
Bob Hope Research Center
Miami, FL 33136-1494
mailbox@parkinson.org
http://www.parkinson.org/
Tel: 305-547-6666 800-327-4545 Fla: 800-433-7022
Fax: 305-243-4403

Parkinson's Action Network (PAN)
1000 Vermont Ave. N.W.
Suite 900
Washington, DC 20005
ckonigsberg@parkinsonsaction.org
http://www.parkinsonsaction.org
Tel: 800-850-4726 202-842-4101 Calif: 707-544-1994
Fax: 202-842-4105

Parkinson's Disease Foundation (PDF)
710 West 168th Street
New York, NY 10032-9982
info@pdf.org
http://www.parkinsons-foundation.org
Tel: 212-923-4700 800-457-6676
Fax: 212-923-4778

Shy-Drager/Multiple System Atrophy Support Group, Inc.
2004 Howard Lane
Austin, TX 78728
Don.Summers@shy-drager.com
http://www.shy-drager.com
Tel: 866-SDS-4999 (737-4999)
Fax: 512-251-3315


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All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.


Provided by:
The National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892




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