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Soto's Syndrome Synonym(s): Reviewed 07-01-2001 Get Web page suited for printing Email this to a friend or colleague Studies with patients Table of Contents (click to jump to sections) What is Soto's Syndrome?Is there any treatment? What is the prognosis? What research is being done? Organizations What is Soto's Syndrome? Soto's syndrome is a rare genetic disorder characterized by excessive physical growth during the first 2 to 3 years of life. The disorder may be accompanied by mild mental retardation, delayed motor, cognitive, and social development, hypotonia (low muscle tone), and speech impairments. Children with Soto's syndrome tend to be large at birth and are often taller, heavier, and have larger heads (macrocrania) than is normal for their age. Symptoms of the disorder, which vary among individuals, include a disportionately large and long head with a slightly protrusive forehead, large hands and feet, hypertelorism (an abnormally increased distance between the eyes), and downslanting eyes. Clumsiness, an awkward gait, and unusual aggressiveness or irritability may also occur. Although most cases of Soto's syndrome occur sporadically, familial cases have also been reported. Is there any treatment? What is the prognosis? What research is being done? Sotos Syndrome Support Association
The Arc of the United States
March of Dimes Birth Defects Foundation
National Organization for Rare Disorders (NORD)
National Institute of Child Health and Human
Development (NICHD)
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