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  Lennox-Gastaut Syndrome 
  
Reviewed  11-06-2001  

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What is Lennox-Gastaut Syndrome?
Is there any treatment?
What is the prognosis?
What research is being done?

Organizations

What is Lennox-Gastaut Syndrome?
Lennox-Gastaut syndrome is a severe form of epilepsy (a seizure disorder). It usually develops in children between 1 and 8 years old and is characterized by several types of seizures, developmental delay, and behavioral disturbances such as poor social skills and attention-seeking behavior. Most children with Lennox-Gastaut syndrome experience some degree of impaired intellectual functioning or information processing. The disorder may be caused by brain injury, severe brain infections, genetic brain diseases, or developmental malformations of the brain. In some cases, no cause can be found. Seizure types, which vary among patients, include tonic (stiffening of the body, upward deviation of the eyes, dilation of the pupils, and altered respiratory patterns), atonic (brief loss of muscle tone and consciousness, causing abrupt falls), atypical absence (staring spells), and myoclonic (sudden muscle jerks). There may be periods of frequent seizures mixed with brief, relatively seizure-free periods.

Is there any treatment?
Treatment for Lennox-Gastaut syndrome may include anti-epileptic medication to control seizures. However, the types of seizures associated with Lennox-Gastaut syndrome are generally difficult to control due to their resistance to most anti-epileptic drugs.

What is the prognosis?
The prognosis for individuals with Lennox-Gastaut syndrome varies. There is no cure for the disorder. Complete recovery including freedom from seizures and normal development is very unusual.

What research is being done?
The NINDS conducts and supports a broad program of basic and clinical research on epilepsy including Lennox-Gastaut syndrome. These studies are aimed at finding the causes of these disorders, improving the diagnosis, and developing new medications and other therapies.

Select this link to view a list of studies currently seeking patients.

 Organizations

Epilepsy Foundation
4351 Garden City Drive
Suite 500
Landover, MD 20785-7223
postmaster@efa.org
http://www.epilepsyfoundation.org
Tel: 301-459-3700 800-EFA-1000 (332-1000)
Fax: 301-577-2684


NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history.

All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.


Provided by:
The National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892




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