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  Devic's Syndrome 
Synonym(s):  Neuromyelitis Optica
Reviewed  03-26-2003  

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Table of Contents (click to jump to sections)

What is Devic's Syndrome?
Is there any treatment?
What is the prognosis?
What research is being done?

Organizations

What is Devic's Syndrome?
Devic's syndrome is a rare autoimmune central nervous system disorder characterized by transverse myelitis (in which the fatty, protective covering of the spinal cord breaks down) and optic neuritis (in which inflammation of the optic nerve causes loss of vision and eye pain).]. It is considered a special form of multiple sclerosis (MS) with a severe and rapid course. The disorder affects the optic nerve and the nerves in the spinal cord. In Devic's syndrome, the fatty sheath that protects these nerves is lost. Individuals may experience vision impairment and various degrees of paralysis, as well as incontinence. The disorder is closely linked with MS and lupus, but usually appears before any symptoms of MS are noted. If an isolated disease episode affecting the spinal cord and optic nerve occurs after an infection or common cold, it is considered a post-infectious acute demyelinated encephalomyelitis (ADE) rather than Devic’s syndrome.

Is there any treatment?
There is currently no standard treatment for Devic's syndrome. Generally, treatment is symptomatic and supportive. Corticosteroids may be prescribed. Treatment for ADE may include corticosteroids, intravenous immunoglobulin, and intravenous methylprednisolone

What is the prognosis?
Devic's syndrome is fatal in many patients. Some ADE patients achieve complete or nearly complete recovery while others may have residual deficits. Some severe cases of ADE may be fatal.

What research is being done?
The NINDS supports an extensive research program of basic studies to increase understanding of how the nervous system works. A major goal of this research is to develop methods for repairing damaged nerves and restoring full use and strength to injured areas.

Select this link to view a list of studies currently seeking patients.

 Organizations

Multiple Sclerosis Foundation
6350 North Andrews Avenue
Ft. Lauderdale, FL 33309-2130
support@msfocus.org
http://www.msfocus.org
Tel: 954-776-6805 888-MSFocus (673-6287)
Fax: 954-351-0630

National Eye Institute (NEI)
National Institutes of Health
Bldg. 31, Rm. 6A32
Bethesda, MD 20892-2510
2020@b31.nei.nih.gov
http://www.nei.nih.gov
Tel: 301-496-5248 Professionals 800-869-2020

National Organization for Rare Disorders (NORD)
P.O. Box 1968
(55 Kenosia Avenue)
Danbury, CT 06813-1968
orphan@rarediseases.org
http://www.rarediseases.org
Tel: 203-744-0100 Voice Mail 800-999-NORD (6673)
Fax: 203-798-2291


NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history.

All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.


Provided by:
The National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892




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