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  Dermatomyositis 
  
Reviewed  11-08-2001  

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Table of Contents (click to jump to sections)

What is Dermatomyositis?
Is there any treatment?
What is the prognosis?
What research is being done?

Organizations
Related NINDS Publications and Information

What is Dermatomyositis?
Dermatomyositis is one of a group of acquired muscle diseases called inflammatory myopathies. The disease, which has a subacute (somewhat short and relatively severe) onset, affects both children and adults. Females are more often affected than males. Dermatomyositis is characterized by a rash accompanying, or more often, preceding muscle weakness. The rash is described as patchy, bluish-purple discolorations on the face, neck, shoulders, upper chest, elbows, knees, knuckles, and back. Some patients may also develop hardened bumps of calcium deposits under the skin. The most common symptom is muscle weakness, usually affecting those muscles that are closest to the trunk of the body (proximal). Eventually, patients have difficulty rising from a sitting position, climbing stairs, lifting objects, or reaching overhead. In some cases, distal muscles (those not close to the trunk of the body) may be affected later in the course of the disease. Trouble with swallowing (dysphagia) may occur. Occasionally, the muscles ache and are tender to touch. Patients may also feel fatigue and discomfort and have weight loss or a low-grade fever.

Is there any treatment?
Treatment for dermatomyositis generally consists of a steroid drug called prednisone. For patients in whom prednisone is not effective, other immunosuppressants such as azathioprine and methotrexate may be prescribed. Recently, a drug called intravenous immunoglobulin was shown to be effective and safe in the treatment of the disease. Physical therapy is usually recommended to preserve muscle function and avoid muscle atrophy.

What is the prognosis?
Most cases of dermatomyositis respond to therapy. The disease is usually more severe and resistant to therapy in patients with cardiac or pulmonary problems.

What research is being done?
The NINDS conducts and supports a broad range of research on neuromuscular disorders such as inflammatory myopathies. The goals of these studies are to conduct therapeutic trials to increase understanding of the disorders and, ultimately, to find ways to prevent and cure them.

Select this link to view a list of studies currently seeking patients.

 Organizations

American Autoimmune Related Diseases Association
22100 Gratiot Avenue
Eastpointe
East Detroit, MI 48201-2227
aarda@aol.com
http://www.aarda.org
Tel: 586-776-3900 800-598-4668
Fax: 586-776-3903

Muscular Dystrophy Association
3300 East Sunrise Drive
Tucson, AZ 85718-3208
mda@mdausa.org
http://www.mdausa.org/
Tel: 520-529-2000 800-572-1717
Fax: 520-529-5300

Myositis Association
755 Cantrell Avenue
Suite C
Harrisonburg, VA 22801
maa@myositis.org
http://www.myositis.org
Tel: 540-433-7686
Fax: 540-432-0206

National Organization for Rare Disorders (NORD)
P.O. Box 1968
(55 Kenosia Avenue)
Danbury, CT 06813-1968
orphan@rarediseases.org
http://www.rarediseases.org
Tel: 203-744-0100 Voice Mail 800-999-NORD (6673)
Fax: 203-798-2291

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institutes of Health
Bldg. 31, Rm. 4C05
Bethesda, MD 20892-2350
NIAMSInfo@mail.nih.gov
http://www.nih.gov/niams
Tel: 301-496-8188 877-22-NIAMS (226-4267)

Related NINDS Publications and Information

  • NIH Myositis Outcomes Workshop

  • Health Disparities Working Group Meeting: Cognitive and Emotional Health Myositis Outcomes Workshop


    NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history.

    All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.


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    National Institutes of Health
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