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  Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) 
  
Reviewed  07-01-2001  

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What is Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)?
Is there any treatment?
What is the prognosis?
What research is being done?

Organizations
Related NINDS Publications and Information

What is Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)?
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological disorder characterized by slowly progressive weakness and sensory dysfunction of the legs and arms. The disorder, which is sometimes called chronic relapsing polyneuropathy, is caused by damage to the myelin sheath of the peripheral nerves. The myelin sheath is the fatty covering—which acts as an insulator—on fibers in the nerves. Although it can occur at any age and in both genders, CIDP is more common in young adults, and in men more so than women. Symptoms include tingling or numbness (beginning in the toes and fingers), weakness of the arms and legs, aching pain in the muscles, loss of deep tendon reflexes (areflexia), fatigue, and abnormal sensations. CIDP is closely related to acute Guillain-Barré syndrome and it is considered the chronic counterpart of the acute disease.

Is there any treatment?
Treatment for CIDP includes corticosteroids such as prednisone, which may be prescribed alone or in combination with immunosuppressant drugs. Plasmapheresis (plasma exchange) and intravenous immunoglobulin (IVIg) therapy are effective. IVIg may be used even as a first-line therapy. Physiotherapy may improve muscle strength, function and mobility, and minimize the development of contractures.

What is the prognosis?
The course of CIDP varies widely among individuals. Some may have a bout of CIDP followed by spontaneous recovery, while others may have many bouts with partial recovery in between relapses. The disease is a treatable cause of acquired neuropathy and initiation of early treatment to prevent loss of nerve cells is recommended. However, some individuals are left with some residual numbness or weakness.

What research is being done?
The NINDS supports a broad program of research on disorders of the nervous system, including CIDP. Much of this research is aimed at increasing understanding of these disorders and finding ways to prevent, treat, and cure them.

Select this link to view a list of studies currently seeking patients.

 Organizations

American Autoimmune Related Diseases Association
22100 Gratiot Avenue
Eastpointe
East Detroit, MI 48201-2227
aarda@aol.com
http://www.aarda.org
Tel: 586-776-3900 800-598-4668
Fax: 586-776-3903

Guillain-Barre Syndrome Foundation International
P.O. Box 262
Wynnewood, PA 19096
info@gbsfi.com
http://www.gbsfi.com
Tel: 610-667-0131
Fax: 610-667-7036

Related NINDS Publications and Information

  • Guillain-Barre Syndrome

  • Guillain-Barre Syndrome information sheet compiled by NINDS.

  • Fact Sheet: Guillain-Barre Syndrome

  • Guillain-Barrè Syndrome (GBS) fact sheet produced by the National Institute of Neurological Disorders and Stroke (NINDS).

  • El Síndrome de Guillain-Barré

  • Información del Sindrome de Guillain-Barre/Spanish-language information on Guillain-Barre Syndrome compiled by the National Institute of Neurological Disorders and Stroke (NINDS).


    NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history.

    All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.


    Provided by:
    The National Institute of Neurological Disorders and Stroke
    National Institutes of Health
    Bethesda, MD 20892




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